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Boehringer Ingelheim raises the bar in biopharmaceutical production

Filling and isolator equipment brings a whole new level of flexibility to the manufacturing of biopharmaceuticals, meeting today's requirements as well as tomorrow's.

With the Bosch filling line, Boehringer Ingelheim can fill and close up to 400 containers/min, ranging from vials to single and double-chamber cartridges. Here, workers check the disposable tubes of the filling system.
With the Bosch filling line, Boehringer Ingelheim can fill and close up to 400 containers/min, ranging from vials to single and double-chamber cartridges. Here, workers check the disposable tubes of the filling system.

Microbes follow people everywhere—even into the highest-grade cleanrooms. Isolators can provide a remedy by separating people, machines, and pharmaceuticals to ensure the highest purity standards for the aseptic manufacture of biopharmaceuticals.

Pharmaceutical manufacturer Boehringer Ingelheim’s new facility in Biberach an der Riss, Germany, fulfils those requirements, winning the 2014 Facility of the Year Award (FOYA) from ISPE, the International Society for Pharmaceutical Engineering.

Equipped with filling and isolator technology from Bosch Packaging Technology, the facility was recognized in the equipment innovation category for the successful implementation of a flexible and transparent production facility for biopharmaceuticals. The plant uses aseptic manufacturing, providing flexible and transparent production of biopharmaceutical products in all important dosage forms.

Boehringer Ingelheim is among the world’s top 20 pharmaceutical companies, focusing on research, development, production, and marketing of high-quality therapies for use in human and animal medicine. In Biberach, Boehringer Ingelheim operates Europe’s largest facility for the development and manufacturing of pharmaceuticals with biotechnologically produced active ingredients, both for its own business and for contract manufacturing.

Aseptic production requirements

To increase its flexibility and capacity at this site, the company decided to expand and modernize the production of biopharmaceuticals. After two years of concept development and design studies, the company initiated an ambitious project involving the construction of two ultramodern filling lines with a joint connection to two freeze dryers in an existing production building.

“Our goal was to create a flexible production area for the manufacturing of all important biopharmaceutical dosage forms. It was supposed to meet today´s and future requirements for aseptic processing while allowing transparent and flexible production,” explains Dr Friedrich Haefele, Vice President BP Fill & Finish Germany at Boehringer Ingelheim.

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