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CRISPR technology embarks on ‘Fantastic Voyage’: What is packaging’s role? Part I

Introducing CRISPR, a gene-editing tool the presents enormous therapeutic potential, but also packaging and handling challenges.

Introducing CRISPR, a gene-editing tool the presents enormous therapeutic potential, but also packaging and handling challenges.
Introducing CRISPR, a gene-editing tool the presents enormous therapeutic potential, but also packaging and handling challenges.

Perhaps some of you can remember the 1966 science fiction film Fantastic Voyage, in which a crew of experts were shrunk into a microscopic-sized submarine to venture through the body of an injured scientist in an effort to repair damage to his brain.

Although such a journey once did seem “fantastic,” developing genomic research and gene editing tools may make disease repairs possible inside humans and animals. CRISPR, or Clustered Regularly Interspaced Short Palindromic Repeats, is just such a tool.

According to Harvard University’s Graduate School of Arts and Sciences, CRISPR represents, “a revolution [that] has seized the scientific community. …and it has changed not only the way basic research is conducted, but also the way we can now think about treating diseases.”

In a May 26, 2017 Wired article, “CRISPR kills HIV and eats Zika ‘like Pac-man.’ It’s next target? Cancer,” author Victoria Woollaston pointed to CRISPR-related HIV research, noting: “Since the HIV research was published, a team of biologists at University of California, Berkeley, described 10 new CRISPR enzymes that, once activated, are said to ‘behave like Pac-Man’ to chew through RNA in a way that could be used as sensitive detectors of infectious viruses.”

Although the technology has applications in agriculture, materials manufacturing, and energy, CRISPR as a gene-editing tool enables precise molecular changes within DNA coding in an effort to treat human illnesses caused by genetic mutations. The technology packs the potential to treat—and ideally cure—virtually thousands of diseases, according to a recent 60 Minutes report. By correcting defective genes, the hope is it could eventually eradicate many chronic or deadly diseases. But will CRISPR be a medical miracle—a panacea for all that ails us?

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Researched List: Engineering Services Firms