Contract pharma manufacturer invests in both liquid and tube filling

Versatility and higher speeds are the two key benefits enjoyed by this Italian contract manufacturer of pharmaceutical products since two new packaging lines were installed.

Shortly after HDPE bottles have been unscrambled and oriented on Doppel’s new liquids line, the bottles are inverted and cleaned with a burst of purified air.
Shortly after HDPE bottles have been unscrambled and oriented on Doppel’s new liquids line, the bottles are inverted and cleaned with a burst of purified air.

In the world of contract manufacturing and packaging, versatility and ease of changeover go a long way. Just ask the folks at Doppel Farmaceutici, the pharmaceutical contract packaging powerhouse located just south of Milan, Italy.
Recent installations at Doppel’s plant in Cortemaggiore, Italy, have brought tremendous advantages (see also www.bit.ly/pwe00446). A new line for filling liquids into high-density polyethylene bottles is a perfect example, says Sabina Gualazzini, production manager at Doppel.


“On this one new line we can produce lots of formats, bottle shapes, and cap varieties,” says Gualazzini. “First of all, we can handle 100-, 200-, 300-, 400-, or 500-mL bottles. Packaging formats vary, too. For vaginal douche we fill an oval bottle and apply a device for application plus an overcap. For an over-the-counter skin disinfectant product we use a round bottle and apply a dispensing plug plus overcap. For cough syrup we fill a round bottle and apply a different style of child-proof closure plus a measuring-cup overcap. This kind of flexibility is very important to us.”


Primary packaging on the new liquids line is done inside a filling room where temperature and humidity are carefully controlled and all machines use filtered, compressed air. Just outside is secondary packaging equipment. Nearly everything inside the filling room was supplied by RAV Sistemi s.r.l., beginning with a bottle unscrambler. Bagged bottles are emptied by an operator into a floor-level bin. A flighted elevator brings bottles to a rotary unscrambler/orienter from which bottles exit single-file on a belt conveyor. Next is a machine that blows purified air into the containers to clean them. Each container is captured in the pocket of a wheel and inverted as a blowing nozzle enters to blow the purified air. As the wheel nears the completion of its 360-degree rotation, the bottles are discharged single-file onto a conveyor leading to the 12-station, intermittent-motion, linear filling machine.


A feed screw meters bottles into the filler and halts their forward progress when each is positioned beneath a fill nozzle. The nozzles descend for filling and retract when filling is complete so that bottles can then be discharged by the feed screw. Doppel fills in one of two ways. If only one product component is involved, 12 bottles are filled simultaneously. But when a product contains more than one component, the feed screw advances six bottles per cycle. Nozzles 1-6 fill component A and then the feed screw advances bottles another six positions so that Nozzles 7-12 can fill component B.


Four-station capping system


Exiting the filler, bottles enter a starwheel that meters them into the intermittent-motion, four-station capping system. At the heart of this system is a pocketed wheel that takes the bottles in pairs from station to station. In the first station, a reciprocating device strokes back to pick two polypropylene plug dispensers from a magazine feed and then strokes forward to insert the plugs into a pair of bottles. In station two, a similar device strokes back and forth to place caps on a pair of bottles. In station three the caps are torqued. Station four, not in use on the day of our visit, is used to place a measuring cap overcap.

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