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Panacea’s Cancer Vaccine Delivered Direct to Dermis

Panacea Pharmaceuticals’ Phase 1 clinical study of an innovative cancer vaccine reaches a milestone by dosing its first patient directly to the dermis via a 3M Hollow Microstructured Transdermal System.

Panacea Pharmaceuticals’ Phase 1 clinical study of an innovative cancer vaccine reaches a milestone by dosing its first patient directly to the dermis via a 3M Hollow Microstructured Transdermal System.
Panacea Pharmaceuticals’ Phase 1 clinical study of an innovative cancer vaccine reaches a milestone by dosing its first patient directly to the dermis via a 3M Hollow Microstructured Transdermal System.

Early in 2017, Gaithersburg, MD-based Panacea Pharmaceuticals, Inc. announced that its first patient was enrolled and dosed in an open-label, parallel-designed, multi-center Phase I clinical trial to assess safety and immunogenicity of PAN-301-1 for the treatment of persistent prostate cancer.

The clinical trial vaccine is delivered through intradermal injection using 3M Drug Delivery Systems’ hollow microstructured transdermal system (hMTS). It is delivered as “a quick injection via the hMTS, which is a patient-friendly microneedle delivery solution that is found to be less intimidating in human factors and other studies,” according to both Panacea and 3M.

The development exemplifies the ongoing progress in cancer vaccine efforts, which can also be used when given in combination with other cancer therapies. The National Cancer Institute’s website identifies two broad types of cancer vaccines:

• Preventive (or prophylactic) vaccines—intended to prevent cancer from developing in healthy people

• Treatment (or therapeutic) vaccines—intended to treat an existing cancer by strengthening the body’s natural immune response against the cancer. Treatment vaccines are a form of immunotherapy.

Partners reach a milestone

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