High on the minds of the healthcare industry is the state of predictive technology for cold chain failures. Transporting medicines and vaccines at appropriate, consistent temperatures is a persistent challenge with current real-time monitoring taking on a passive role as excursions cannot always be acted upon in time.
According to a Technavio report, the global cold chain logistics market is expected to grow by USD 9.37 billion from 2021 to 2025 at a CAGR of 9.03%. Yet, data reports show that 25% of vaccines are damaged due to cold chain malfunction, such as improper distribution and shipping. The data further shows that in some countries, about 80% of drugs are estimated to lose their potency due to inadequate temperature control during cold chain transportation. All of which results in money loss for the industry as well.
As the pandemic has settled in and vaccines have been made to protect the global population, this concern remains of utmost importance.
The current state of cold chain
The current industry practice is to use standard ambient profiles, lane ambient profiles, and lane risk assessments. Organizations base their decision of which shipper to use on these profiles. Custom ambient profiles can be made for a shipping lane over a period of a few years or more, which might provide better insight into the thermal stress the shipper could experience during transportation. However, this process is arduous and complex and these profiles cannot account for all real-world events.
Real-time monitoring devices can transfer real-time location and some amount of condition and sensor data, which can be accessed to inform on the package’s journey. Default settings can include geo-fencing and binary high/low threshold sensor parameter alerts, but these have incomplete insights and are not always actionable in real-time.
Advancements in predictive technology
MaxTrace is an “active prediction” technology.
Saravan Kumar, CEO of MaxQ presented his company’s latest research and technology at the Forum, called MaxTrace, which he refers to as “active prediction” technology. Being alerted to an excursion occurring in real-time doesn’t necessarily allow the brand owner or 3PL to intervene. The company wanted to design a real-time monitoring system that would generate alerts as soon as a breach was predicted—well in advance of the breach actually occurring—allowing sufficient time to stop the temperature excursion. Such a system would increase efficiency, reduce wastage, confirm product safety, and ensure patient safety.
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MaxTrace is a proprietary predictive cloud engine, designed to provide real-time actionable insights about the thermal life of each shipper and it creates a digital twin to accurately predict how long the box can maintain its required internal condition. This engine analyzes temperatures, journey duration, lane risk factors, external weather data sources, machine learning intelligence and more.
“We came up with a way to develop a cold chain container-specific digital twin, which we then deployed as a predictive cloud engine. It then takes all real-time signals and a bunch of different caveat signals and variables, and it allows us to automate predicting and preventing temperature excursions,” said Kumar.
Kumar listed the following as the four key areas where excursion losses occur:
- conditioning error
- packing error
- tarmac exposure
- shipment delays
To avoid these occurrences, MaxTrace gathers three performance indicators, which are the current state of the packaging, coolants, and insulation; lane parameters; and the expected ambient circumstance the container will face. “If we knew all three different parameters, to a certain extent I can predict what the performance of this container is going to be,” Kumar explained.
The function of the digital twin of the container, developed through a pseudo-analytical model, is to reflect the behavior of the container in real-time. This requires real-time input from IoT devices that are integrated with the container.
Qualification data for the container along with trial shipments in real-time are used to calibrate the digital twin.
This cloud engine is designed to provide predictions up to three hours in advance to allow for preventative actions for both active and passive containers, as well as for business and logistic process integrations, through rerouting and returning the shipments.
The goal is for the whole process to become totally automated through prediction and prevention. Benefits beyond excursion prevention include a scalable architecture that is container-agnostic, IoT device-agnostic, and accepting of a variety of data sources.
Concerns in implementing the new technology
As a new process, there are challenges that the company is striving to remediate. The biggest challenge is validating the digital twin-based predictive model as it uses a wide range of factors. Real-time monitoring programs are also expensive, the agility of logistics processes to execute the prescribed action needs improvement, and it can be a challenge to help people understand that the SOP is dynamic.
Mark Maurice, a solutions consultant at Sensitech, further explained that what’s missing are sophisticated workflows with freight carriers and others within other industries. Someone must be available around the clock in the case the preventative action is required to head off a temperature excursion.
Regulatory compliance issues Maurice touched on are:
- The sustainability of the monitors in using single- or multi-use real-time monitors. In the case of multi-use monitors, the devices would need to be transported back to their origin. There could be a refurbishment process put in place where the device is taken to a local refurbishment location. However, Maurice noted, monitoring systems that are reused will require upgrades in firmware and software as well as cell communications.
- Balancing the inventory of monitors as some may be lost or damaged. There is a cost to resetting and reconfiguring these devices. “You have to couple your sustainability plan with what it’s going to cost and balance that between multi-use in packaging and multi-use in monitoring,” Maurice said.
Maurice also emphasized that the way to manage shipments going through multiple climates is through machine learning. The ability to react quickly when an excursion is predicted is by having the optimal solution provided to the company through the machine learning intelligence. Humans on their own take up too much time to come to the conclusion of what solution is the most efficient, according to Maurice. In the case of a universal pack-out, for example, analytics can lead a company with the most cost-effective seasonal shipper or right shipper considering where the product is being shipped to, managing both quality and cost. “But you can’t do that in your mind, right now, you can’t think of all those variables, the weight of the package, the qualifications, how long, which package to use,” Maurice said. “Predictive models can get us there.”
Multivariable analysis through machine learning is the future of monitoring, according to Maurice, as it would allow for the system to define the pack-out to use for a shipment, driving large quality and cost solutions.
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