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GlaxoSmithKline reduces product lead times

Liquid-filled hard capsules replace soft gelatin capsules, which also integrate well with GSK’s capsule-filling equipment.

Capsugel Licaps
Capsugel Licaps

After initially launching its GRANU FINK® product for the urological market in Germany in a soft gelatin capsule form, GSK’s Consumer Healthcare Division decided to investigate other dosage form options to try and improve the product’s quality and reduce its production-to-market lead time.

The company selected Licaps® liquid-filled hard capsules from Capsugel, a provider of dosage form solutions to the healthcare industry.

GRANU FINK’s active ingredients, pumpkin seeds extracts and pumpkin oil, were challenging to encapsulate because of the large particle size and required a long maturing period when encapsulated in traditional softgel capsules. After testing a switch to Capsugel’s Licaps technology, GSK found the product to be leak-free and have now reduced their product lead times by 12 weeks.
Dr. Stephan Wurtz, head of production at GSK in Herrenberg, explains, "After comparing two different automated capsule sealing techniques, the Licaps capsules had intact seals during the complete period of stability testing and we could not detect any leakage. Capsule integrity is a key parameter used to predict product shelf life and especially helps with preventing too many product returns and this is why we ultimately chose the Licaps liquid-filled hard capsules as our dosage form."

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