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Article | August 31, 2004
Film test results (sidebar)
Nephron has for months conducted pouch film material assessments to qualify or requalify packaging materials and its material vendors. Specifically, it’s testing pouch material used to package the low-density polyethylene vials containing the product solutions.
Conducted in-house and by outside labs that can identify any impurities the pouch materials are tested for barrier and residual solvents along with real-world stability tests.
Supplied in roll form Nephron’s pouch materials use foil laminations to provide a barrier to light and the exterior atmosphere. A typical laminated structure is polyester/ink/solvent/aluminum foil according to former company president Steve Simmons.
Simmons points out that packaging and packaging processes such as heat sealing can generate volatiles from the solvents used. Without the proper barrier and under certain conditions these solvents could migrate through the low-density polyethylene vials into the product solutions in trace amounts.
Nephron has conducted stringent testing of 12 different substrates from eight vendors to test the materials and suppliers. Engineering manager Eric Heussi also points out that the materials must also pass a production test run to guarantee machinability. The results have been finalized to the following three approved vendors the first two of which Nephron currently uses and the third of which is also qualified according to Heussi: Phenix Label Flexicon and Winpak.
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